Tools for Electrophysiology and imaging

Tool-building is an essential part of our efforts. We have developed computer systems for virtual-reality-inspired electrophysiology, mouse lines for calcium imaging, and scanning methods for high-speed imaging of user-identified cells.

Relevant Publications

Patel YA, George A, Dorval AD, White JA, Christini D, Butera RJ (2017) Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI). PLoS Computational Biology 13: e1005430.

Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermal M, Morris SC, Talbot A, Palumbos S, Ichida J, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA†, and Tvrdik P† (2014) Imaging activity in neurons and glia with a new GCaMP5G reporter mouse. Neuron 83: 1058-1072. (†: co-senior authors).

Lillis KP, Eng A, White JA, and Mertz J (2008) Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution. Journal of Neuroscience Methods 172: 178-184.